2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-105321A
    PBT 1033 hydrochloride 648896-70-2 98%
    PBT 1033 hydrochloride is an orally active copper/zinc ionophore. PBT 1033 hydrochloride restores cognition in mouse models of Alzheimer's disease (AD). PB 1033 also has antibacterial activity against Gram-positive bacteria.
    PBT 1033 hydrochloride
  • HY-105521A
    Dexnafenodone hydrochloride 94096-42-1 98%
    Dexnafenodone hydrochloride ((S)-Nafenodone) as an antidepressant compound, is a potent and selective inhibitor of the synaptosomal uptake of noradrenaline, but has a less potent effect on serotonin uptake and a negligible effect on dopamine uptake.
    Dexnafenodone hydrochloride
  • HY-105545C
    Dexetimide hydrochloride 21888-96-0 98%
    Dexetimide hydrochloride ((+)-Benzetimide hydrochloride) is an antimuscarinic drug with the activity of suppressing neuroleptic-induced Parkinson's syndrome. Dexetimide hydrochloride is used to improve the symptoms of movement disorders caused by the use of neuroleptics. Dexetimide hydrochloride, as the (-)-enantiomer of (-)-Benzetimide, shows the ability to selectively inhibit cholinergic receptors.
    Dexetimide hydrochloride
  • HY-105747A
    Guanoxyfen nitrate 860385-36-0 98%
    Guanoxyfen (N-(3-Phenoxypropyl)guanidine) nitrate is a compound that exhibits potent inhibitory activity against the serine protease enzyme TMPRSS2, which plays a crucial role in the infectivity of coronaviruses. Guanoxyfen nitrate is also an effective inhibitor of vasoconstrictor responses to sympathetic nerve stimulation.
    Guanoxyfen nitrate
  • HY-105772A
    Lometraline hydrochloride 30060-91-4 98%
    Lometraline hydrochloride is an aminotetralin derivative and can be used for Parkinson's disease research.
    Lometraline hydrochloride
  • HY-105791S
    Sulazepam-d5 98%
    Sulazepam-d5 is a deuterium labeled Sulazepam (HY-105791). Sulazepam is a selective ovarian cancer G protein-coupled receptor (OGR1) agonist.
    Sulazepam-d5
  • HY-105853S
    Pitofenone-d4 98%
    Pitofenone-d4 is deuterium labeled Pitofenone (HY-105853). Pitofenone, a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with Kis of 36 and 45 μM, respectively.
    Pitofenone-d4
  • HY-105960A
    Fenmetozole hydrochloride 23712-05-2 98%
    Fenmetozole hydrochloride is an antagonist of ethanol, and also antagonizes α2-adrenergic receptor, which has antidepressant effect.
    Fenmetozole hydrochloride
  • HY-106157A
    Donitriptan mesylate 200615-15-2 98%
    Donitriptan Mesylate is a potent, high efficacy agonist at 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively.
    Donitriptan mesylate
  • HY-106361A
    Flerobuterol hydrochloride 82101-08-4 98%
    Flerobuterol hydrochloride is a beta-adrenoceptor agonist with antidepressant activity. Flerobuterol hydrochloride enhances serotonergic neurotransmission.
    Flerobuterol hydrochloride
  • HY-106454R
    N-Desalkylflurazepam (Standard) 2886-65-9
    N-Desalkylflurazepam (Standard) is the analytical standard of N-Desalkylflurazepam. This product is intended for research and analytical applications. N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC50 values of 55 μM and 37 μM for Cav1.2 and Cav1.3, respectively.
    N-Desalkylflurazepam (Standard)
  • HY-106617A
    Etoperidone hydrochloride 57775-22-1 98%
    Etoperidone hydrochloride, an antidepressant agent, is an orally active serotonin and nor-adrenaline re-uptake antagonist. Etoperidone hydrochloride shows Kd values of 36 nM, 38 nM, 85 nM, and 570 nM for 5-HT2 receptor, α1-adrenergic receptor, 5-HT1A receptor, and α2-adrenergic receptor, respectively.
    Etoperidone hydrochloride
  • HY-106644A
    Femoxetine hydrochloride 56222-04-9 98%
    Femoxetine hydrochloride is a serotonin (5-HT) inhibitor with antidepressant properties. Femoxetine hydrochloride increases serotonin levels in the brain by preventing serotonin from being reabsorbed by nerve cells, resulting in increased concentrations of the neurotransmitter in the synaptic gap, which enhances serotonin signaling. Femoxetine hydrochloride can be used to study the role of serotonin in depression and other emotional disorders, and how 5-HT reuptake inhibitors affect mood and behavior.
    Femoxetine hydrochloride
  • HY-106769A
    (3aR,9aR)-Fluparoxan hydrochloride 105226-30-0 98%
    (3aR,9aR)-Fluparoxan ((3aR,9aR)-GR50360) hydrochloride is a compound that can be used to synthesize and prevent and improve neurodevelopmental disorders.
    (3aR,9aR)-Fluparoxan hydrochloride
  • HY-106769C
    Fluparoxan hydrochloride 105227-44-9 98%
    Fluparoxan hydrochloride is an orally active, selective and competitive alpha 2-adrenoceptor antagonist. Fluparoxan hydrochloride is an anti-depressant agent.
    Fluparoxan hydrochloride
  • HY-106832A
    Vatanidipine hydrochloride 133743-71-2 98%
    Vatanidipine (Watanidipine) hydrochloride is an orally active dihydropyridine (DHP)-type calcium channel blocker and a useful antihypertensive agent. Vatanidipine hydrochloride shows vasodilatory effects and also suppresses noradrenaline release from sympathetic nerve endings.
    Vatanidipine hydrochloride
  • HY-106874A
    Delequamine hydrochloride 119942-75-5 98%
    Delequamine (RS-15385-197) hydrochloride is an orally active and selective α2-adrenergic receptor antagonist with a pKi of 9.5 for α2-adrenoceptors in rat cortex. Delequamine hydrochloride shows >1000 fold selectivity against 5-HT1A receptors and α1-adrenoceptors. Delequamine hydrochloride can be used for the study of erectile dysfunction.
    Delequamine hydrochloride
  • HY-106874B
    rel-Delequamine 119813-87-5 98%
    rel-Delequamine (rel-RS-15385-197) is an orally active, brain-penetrant, potent and selective M2-adrenoceptor antagonist and α2-adrenoceptor antagonist. rel-Delequamine has a pKi of 9.45 for α2-adrenoceptors in the rat cortex. rel-Delequamine augments K+-evoked release of noradrenaline with an EC50 of 1 nM.
    rel-Delequamine
  • HY-106888A
    CS-722 144886-17-9 98%
    CS-722 is a centrally acting muscle relaxant, and has a muscle relaxant activity and depressant effectson the spinal reflex[1]. CS-722 inhibits spontaneous inhibitory postsynaptic currents and excitatory postsynaptic currents in hippocampal cultures probably by an inhibition of both sodium and calcium currents.
    CS-722
  • HY-106933A
    Dabelotine methanesulfonate 153049-48-0 98%
    Dabelotine (methanesulfonate) is a cognitive enhancer. Dabelotine (methanesulfonate) can be used for Alzheimer disease (AD) research.
    Dabelotine methanesulfonate
Cat. No. Product Name / Synonyms Application Reactivity